Production - Fine Chemicals Plant

BABOLNA BIO produces its sophisticated active ingredients in its own multipurpose Fine Chemicals Plant built about 10 years ago. These are complex organic compounds that have to meet such high chemical purity requirements which can be ensured only with sophisticated apparatus, highly qualified man-power and appropriate analytical background.

We have recently made considerable investments to improve the technical standard of the plant. This modernized and expanded facility is now suitable for full synthesis and production of sophisticated pesticides, juvenile hormone analogues and pheromones in scale of tons per year.

The experience gained in the application of various synthesis methods allows production of a number of special key intermediates used in other fields (such as fine chemistry, pharmaceutical, plant protection and fragrance/aroma industry, etc.).

Chemical reactions involving extreme corrosion are performed in the glass and enamel apparatus without the risk of contaminating the product itself.

Synthesis of the S-Methoprene active ingredient is carried out in compliance with GMP which ensures its eligibility for veterinary purposes, too.

For the technological development of the synthesis processes there is an analytical laboratory and a preparatory development laboratory.

Short technical description

Synthesis reactions are made with gradual scale increase from 100 liters up to 3,000 liters.

There is three different vacuum systems according to various technological needs.
The high quality of the active ingredients are ensured with very finely adjustable distillation apparatus (evaporators).

Rotation evaporator:

Büchi (10 dm3)

Rotation wiped film evaporators:

0.2 m2 enamel/glass QVF film evaporator, to use for the purification of heat-sensitive, low-volatile compounds. The system is also suitable to carry out especially dangerous continuous technologies including highly exothermic reactions (such as nitration).

0.1 m2 glass QVF short-path evaporator

Serves for refining and purification of high value, low-volatile, heat-sensitive compounds and, of course, suitable for simpler vacuum distillation tasks, too. The system has its own fine vacuum and heat transfer units.

Routinely applied synthesis processes

  • Esterification

  • N- and O-acylation

  • Hydrolysis

  • Halogenation with elements (Cl2, Br2, I2)

  • Halogenation with inorganic halogenids (SOCl2, PCl3, POCl3, PCl5)

  • Grignard- synthesis

  • Wittig-synthesis